Forensic pathologists face personal and professional challenges in a moody, tense thriller that moves from the crime scene to the lab. 　　Amanda Burton makes a dramatic return to Silent Witness as she reprises her role of Sam Ryan for the 25th anniversary. 　　Amanda first appeared in the lead role of pathologist Sam Ryan in 1996, starring in 54 episodes before leaving in 2004, when her character returned home to Northern Ireland to be with her family. 　　Amanda Burton says: “I am so excited to be returning to Silent Witness and stepping back into Sam Ryan’s shoes - with a difference! Audiences can look forward to plenty of twists and turns as they discover what Sam’s been doing since leaving the Lyell.” 　　Amanda joins fellow cast members Emilia Fox (Nikki Alexander), David Caves (Jack Hodgson) and Genesis Lynea (Simone Tyler) for six brand new episodes which will mark the 25th Anniversary of the hugely popular prime time BBC One drama. 　　Emilia Fox says: “It is such a delight and thrill to be working with Amanda. To have Sam Ryan back again at the heart of the show is the greatest way of all to celebrate the 25th anniversary of Silent Witness.”